A 32 years old man , brought in to ED unresponsive by his friends
On examination: He is unresponsive , hypo-ventilating , RR: 4 , SPO2:70% in r.a and with pinpoint pupils bilateral, PR: 100 . BP: 100/50, blood sugar 4 mmol/l
He was given naloxone 0.4 mg IV X 5 doses , where he walk up and